Hence, serum vascular endothelial growth factor can be used as a more reliable, non-invasive adjunctive diagnostic criteria in the assessment of the grade and hence, the prognosis of malignant tumors of the breast.
Abstract. Podophyllotoxin belongs to the cyclolignan family of natural products. It exhibits cathartic, cytotoxic, antimitotic, anticancer and other biological activities. The new tetralone esters 4, 5, 6 and 7 of podophyllotoxin analogues were synthesized in very good yields by chalcone route. They were synthesized by modifying 1,3-methylene dioxy ring A, ring C, the lactone ring D and the ring E of podophyllotoxin 1 to study structure activity relationship. All the products were characterized by spectral and elemental analysis data.
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