Objective: To evaluate the effects of Omega-3 on PMS. Method: A randomized double blind controlled trial was performed on 184 eligible women. 124 women finally finished the study. In the case group (n=70), Omega-3 and in the control group (n=69) placebo was prescribed. Results: There were no significant differences between the two groups according to age, BMI, level of education, and the severity and duration of primary symptoms. 45 days after commencing Omega-3, the mean severity of depression (1.85±0.73 vs 3.72 ±0.65, P=0.03), anxiety (1.53± 1.04 vs 4.07 ±0.91, P=0.02), lack of concentration (2. 49± 1.26 vs 5.73±1.34 P= 0.03) and bloating (0.95± 0.15 vs 2.31± 0.19 P=0.02) in the case group, were all significantly lower than in the control group. The duration of depression (4.25±1.02 vs 7.21±1.32 days, P=0.04) and bloating (5.53±2.27 vs 8.33±1.04 days, P=0.031) in the case group were less than in the control group. 90 days after commencing the treatment, the mean severity of depression (0.95±0.75 vs 3.43±0.
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