Background and objectives: Major beta thalassaemia is an inherited haemolytic disease that needs regular blood transfusion as a standard treatment. Blood transfusion is generally safe; however, adverse effects can occur and one of which is red cell alloimmunization that can lead to acute or delayed haemolytic transfusion reactions. This study was designed to estimate the prevalence of red cell alloantibodies in patients with thalassaemia in Sri Lanka. Methods:The study was carried out at three tertiary care hospitals of Sri Lanka. Every beta thalassaemia patients transfused with packed red cells were included. Data collected to a form by analysing the cross match request form sent to the blood bank prior to the transfusion.Results: There were 398 patients in all hospitals. 188 (47.24%) of them were males and 210 (52.76%) were females. Mean age was 18.41 (SD=11.67) years. Out of 398 patients, unexpected red cell antibodies are present only in 6 (1.51%) patients. Identified antibodies were Anti E, Anti K, Anti D, Anti C, Anti S, Anti Jk b and autoantibodies. There was one patient who had developed multiple antibodies. Conclusion:Prevalence of red cell antibodies is lower, even though the patients were been transfused without phenotypically matched red cells. Further studies are suggested to decide the practice of Rh and Kell matching for transfusion in patients with beta thalassaemia.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.