BACKGROUNDRhinoscleroma is a chronic inflammatory condition in which deforming masses of tissue distend the nasal cavity. Klebsiella rhinoscleromatis is the causative agent. Antibiotic therapy traditionally consisted of streptomycin and tetracycline. But longterm therapy results in adverse side effects and poor patient compliance, hence this study to search alternative agents.
MATERIALS AND METHODSThis is a prospective study of 60 cases of rhinoscleroma visiting to the Department of ENT, KIMS, for a period of two years.
RESULTSAfter 8 weeks treatment in the atrophic and granulomatous group, 6 (60%) became histopathologically negative and 4 (40%) remained histopathologically positive. The treatment was continued for another 4 weeks in positive cases and at the end of 12 weeks, 8 (80%) turned histopathologically negative, 2 (20%) remained positive.
CONCLUSIONWe conclude that ciprofloxacin is a very good alternative drug compared to doxycycline in the treatment of rhinoscleroma particularly in the early stages of the disease and complete cure can be achieved by early diagnosis and treatment.
KEYWORDSRhinoscleroma Therapy, Ciprofloxacin, Doxycycline.HOW TO CITE THIS ARTICLE: Kallapa S, Sarkar SR, Shankar MG. Effectiveness of ciprofloxacin vs. doxycycline in treatment of rhinoscleroma-A case-control study. J. Evid. Based Med.
More than two thirds of oral cancer patients present in advanced stage in India, from subsites like Buccal mucosa and tongue often present with N3b
nodes with skin involvement. This type of advanced disease usually requires composite resection and extended radical neck dissection. If both the
defects are adjacent to each other can be addressed by bipaddle PMMC. If the signicant normal tissue lies between the primary and neck defects
[level 2b,3,5] it should be Reconstruction with a single free ap or combination of free and locoregional aps. Free ap reconstruction requires
expertise and other ancillary instruments which is difcult to organize in COVID situation. We overcame this problem by designing the PMMC in
a unique manner with two island skin paddles based on the pectoral branch of thoraco-acromial vessels to cover both the defects.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.