Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid dosage forms. In response to this need, a variety of orally disintegrating tablet (ODT) formats were commercialized, which disintegrate within 1 min when placed in the mouth without drinking water or chewing. Oral drug delivery technology has improved from conventional dosage forms to modified release dosage forms to ODT to the recent oral disintegrating films (ODF). Oral disintegrating film or strip that employs a water dissolving polymer which allows the dosage form to quickly hydrate by saliva, adhere to mucosa, and disintegrate within a few seconds, dissolve and releases medication for oromucosal absorption when placed on the tongue or oral cavity. Oral strip technology provides an alternate route for drugs with first pass metabolism. This review give details of materials used in ODF, manufacturing aspects, technologies, evaluation tests and marketed products.

No abstract

No abstract

No abstract

In order to exploit the potential of host-guest interaction of cyclodextrin molecules and the controlled release properties of sodium montmorillonite, we have developed a novel composite hydrogel (CH), namely maleated cyclodextrin-grafted-silylated montmorillonite (MACD-g-MPTMS/MMT) for colon specific tetracycline hydrochloride (TCH) drug delivery. The CH was characterized by using techniques such as FTIR, SEM and XRD. The effect of the pH on the encapsulation of TCH was studied and found to be maximum at pH 3.0. The study of the surface morphology of CH using SEM showed an irregular and rough surface morphology, which favors TCH drug loading. In TCH loaded CH, the shift of the FTIR bands of amide I and II in comparison to crystalline TCH suggested a strong interaction between the amide groups and the clay surfaces. The swelling behavior of CH was measured in different media and found to be a maximum at pH 7.4. The drug delivery results demonstrated that CH could successfully deliver TCH to the colon without losing the drug in the stomach, and could be a good candidate for an orally administered drug delivery system. Results showed that the prepared CH showed good biocompatibility in the range 10-75 mg ml 21 , being also able to effectively stimulate cell proliferation.