For those drugs with more than one study, a previous metaanalysis was performed using Joaquin Primo calculator. An adjusted indirect comparison (IC) of the drugs used in AS versus tofacitinib was performed using the Bucher method, using Joaquin Primo calculator. Due to lack of data in the literature and considering that therapy failure can be recovered with second lines, half of the ASAS40 value obtained in meta-analysis was taken as delta value. ATE guide was followed in order to establish a positioning. ResultsSixteen studies were included 4 adalimumab, 2 golimumab, 1 infliximab, 1 certolizumab, 2 etanercept, 1 upadacitinib, 2 tofacitinib, 1 secukinumab and 2 ixekizumab. The difference in ASAS40 of the drugs before versus tofacitinib expressed as RAR (IC 95%
comprised exclusively platinum-pretreated population. Ado-trastuzumab emtansine showed the best numerical results according to ORR (54.5%), but the worst PFS (2.8 months; 95% CI 1.4-4.4) and OS (8.1 months; 95% CI 3.5-13.2) of all therapeutic alternatives. The highest numerical efficacy results were achieved by amivantamab [PFS = 8.3 months (95% CI 6.5-10.9); OS = 22.8 months (95% CI 14.6 to not reached)] and mobocertinib [PFS = 7.3 months (95% CI 5.5-9.2); OS = 24.0 months (95% CI, 14.6-28.8)]. Conclusion and RelevanceResults of amivantamab and mobocertinib suggested a higher numerical efficacy for clinically relevant endpoints in platinum pre-treated NSCLC harbouring EGFR exon 20 insertions. However, comparative RCTs with larger sample sizes are necessary to obtain reliable data.
Results Seventy-four patients, 64% men, mean age 58.6 years. All of them were high/very high CDV risk (stable or unstable coronary artery disease, ischaemic stroke, transient ischaemic attack or peripheral arterial disease). Eighty per cent presented baseline LDL-C levels higher than 150 mg/dL. Forty (54%) patients reached the targeted range for LDL-C. Thirty-four (46%) patients reached LDL-C levels>70. All of them started with 75 mg every 14 days. Only nine patients (27%) have increased the dose of praluent to 150 mg/14 days in the week 12. Conclusion Dosage adjustments according to LDL-C levels should be followed closely to achieve better outcomes. The dose should be increased to 150 mg every 2 weeks at week 12 if LDL-C is greater or equal to 70 mg/dL at week 8. An adequate organisation and coordination between the different implicated medical services would be desirable, as the dates for monitoring LDL-C and the optimal monitoring interval are already established.
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