Endometrial bleeding problems can be the major reason for discontinuing progestin-only contraception. In this study the endometrial angiogenic response in Norplant users was found to be lower than in women with normal menstrual cycles. These disturbances in angiogenic response may be caused by oxidant-antioxidant imbalance in the endometrium. The aims of this study were to investigate the effect of progestinonly contraceptives on blood concentrations of Iipid peroxide and vitamin E, and the effect of vitamin E supplementation on endometrial angiogenic response in vitro. The subjects for this study were Norplant users, depo-medroxyprogesterone acetate (DMPA) users, and controls. Circulating Iipid peroxide and vitamin E concentration was measured by routine methodology. Endometrial angiogenic response was assayed using an endothelial cell migration assay. The results showed that the blood concentrations of Iipid peroxide from Norplant users with bleeding problems were significantly higher than normal menstrual controls (P < 0.05) and supplementation of vitamin E (in vitro) increased the endometrial angiogenic score. Blood concentrations of Iipid peroxide were significantly increased (P < 0.05), and the blood concentrations of vitamin E were significantly decreased (P < 0.05) after 3 months exposure to Norplant or DMPA. The endometrial angiogenic scores in Norplant and DMPA users were significantly lower than in controls (P < 0.02). It is concluded that in progestin-only contraceptive users, higher Iipid peroxide and lower vitamin E concentration may cause endometrial cell damage and decrease the endometrial angiogenic response. It is suggested that vitamin E supplementation may counteract these unwanted side-effects.
Latar Belakang : Vitamin C adalah vitamin larut air, suplemen multivitamin antioksidan tinggi yang berfungsi melawan radikal bebas serta meregenerasi antioksidan lainnya. Tingginya radikal bebas berpengaruh terhadap fungsi endotel yang mengakibatkan terjadinya resistensi insulin dan berpengaruh terhadap jumlah glukosa darah. Tujuan : Mengetahui rerata kadar glukosa darah puasa, rerata kadar glukosa darah sewaktu setelah diberikan beban glukosa 75 g, glukosa darah sewaktu setelah pemberian konsumsi vitamin C dan mengetahui adanya pengaruh konsumsi suplemen vitamin C terhadap kadar glukosa darah mahasiswa Fakultas Kedokteran Universitas Islam Al - Azhar Mataram Tahun 2018. Metode Penelitian : Penelitian menggunakan metode pre-eksperimental dengan rancangan one grup pretest posttest design. Populasi adalah semua mahasiswa preklinik dengan sampel berjumlah 33 responden yang memenuhi kriteria inklusi. Teknik sampling menggunakan purposive sampling dengan uji statistik uji-t berpasangan. Hasil : Rerata glukosa darah puasa 85,18 mg/dL, glukosa darah sewaktu setelah diberikan beban glukosa 75 g 143,76 mg/dL, dan glukosa darah sewaktu setelah konsumsi vitamin C 110,94 mg/dL. Hasil uji-t berpasangan diperoleh p-value = 0,000 (p- value ≤ α=0,01) dengan IK sebesar 19.210-46.426 mg/dL. Kesimpulan : Dari hasil uji t-berpasangan yang berarti terdapat pengaruh konsumsi suplement vitamin C terhadap kadar glukosa darah pada mahasiswa Fakultas Kedokteran Universitas Islam Al-Azhar Mataram Tahun 2018.
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