We examine the effect of replacing calcium by zinc has on the transport properties of the BiSrCaCuO-2221 system. It is shown that the critical temperatures Tc of the Bi2Sr2CaCu2Ox(B1) and Bi2Sr2ZnCu2Oy(B2) samples are close (81 K and 80.72 K). However, the resistivity ρ of the Bi2Sr2ZnCu2Oy sample increases considerably, and the ratio ρB2/ρB1 ≈ 10 at 100 K. We use the local pair model to analyze the mechanism behind the formation of excess conductivity in Bi2Sr2CaCu2Ox and Bi2Sr2ZnCu2Oy(B2), with consideration of the Aslamazov-Larkin theory near Tc. We determined the temperature T0 of the transition from the 2D fluctuation area to the 3D region (i.e., the 2D-3D crossover temperature). We calculated the coherence length of the fluctuation Cooper pairs along the c axis, ξc(0). It is shown that substituting Zn for Ca reduces ξc(0) by almost 1.5 times (4.8 Å and 3.3 Å, respectively), and also leads to a narrowing of both the pseudogap region and the superconducting fluctuation area near Tc. We determined the temperature dependence of the pseudogap Δ*T and Δ*(Tc). The increase of ρ, its specific temperature dependence and the significant decrease of T* in sample B2, all point to the destruction of local pairs at all high temperatures, i.e., to the suppression of the pseudogap by Zn doping.