The CREATE-ECLA Randomized Controlled TrialThe CREATE-ECLA Trial Group Investigators* See also pp 427 and 489.

No abstract

Cost of milk production is an important economic indicator in assessing the farm household efficiency in milk production as well as basis for price fixation. The study was undertaken to analyse the cost and returns of milk production in rural and periurban dairy farms of Kalaburagi district of Karnataka. The per day maintenance cost in periurban dairy farms (` 150.64) was highest compared to rural dairy farms (` 91.29)for local cows, crossbred cows and buffaloes. Among total maintenance costs of periurban dairy farming, feed and fodder costs accounted major share (73.49%) followed by labour cost (15.53%) and total fixed cost (7.73%). The return per litre of milk was highest (` 8.91) for crossbred cows followed by buffalo (` 4.82) and local cows (` 0.14). The net return from crossbred cow was more than that of buffalo and local cows indicating higher profitability in rearing crossbred cow in the study area.

Sheep and goat play an important role in Indian economy and source of livelihood and employment to millions of rural households. Sheep and goats in India are mostly maintained on natural vegetation on common grazing lands, wastelands and uncultivated (fallow) lands, stubbles of cultivated crops and top feeds (tree loppings). Rarely they are kept on grain, cultivated fodder or crop residue. Sheep and goat rearing is the backbone of the economy of small and landless farmers in India. The study was carried out in Tumakuru, Chitradurga, Belagavi and Kalaburagi districts of Karnataka. The results of the study revealed that majority of the sheep and goat farmers belonged to age group of above 40 years and are illiterate (50-52%). The family size of sheep and goat rearing households have medium size with 4-6 members. The maximum number of farmers were having income of less than `1 lakh per annum, who belonged to backward class, scheduled caste and scheduled tribe. The total number of sheep per household were 25, 67 and 27 under small, medium and large herd size with an overall average of 71 sheep per farm. Similarly, about 17, 29 and 43 goats were found in small, medium and large flock size of goat with an average of 30 goats per flock. Majority of the farmers were having kaccha type of shed for rearing sheep (41.66%) and goat (80%).

The average potassium intake in the United States population ranges from 90 to 120 mEq/day. About 98% of the total body\'s potassium is intracellular, and only 2% is present in the extracellular compartment. This distributional proportion is essential for cellular metabolic reactions and maintaining a gradient for resting membrane potential. A loss of this gradient results in hyper- or hypopolarization of the cell membrane, especially in cardiac muscles leading to life-threatening arrhythmias. Multiple mechanisms in human maintain homeostasis. Transient initial changes are due to transcellular shifts activating sodium-potassium ATPase pumps on the cell membrane. The kidneys essentially take part in excess potassium excretion, maintaining total body stores constant within normal range. Gastrointestinal secretion of potassium is insignificant in individuals with normal renal function, however plays an essential role in individuals with compromised renal function. So far, a classic feedback mechanism was thought to maintain potassium homeostasis; however, a recently recognized feedforward mechanism acting independently also helps preserve potassium homeostasis. Hence, potassium homeostasis is vital for humans to function at a normal level.