Lymphocytes separated from synovial fluid in rheumatoid arthritis by means of gradient centrifugation were characterized with regard to B‐ and T‐lymphocyte properties. Membrane‐bound Ig detectable with immunofluorescence technique was utilized as a marker of B‐lymphocytes, while the ability to bind sheep erythrocytes and form rosettes was interpreted as a T‐lymphocyte characteristic. In 9 out of 18 patients studied no Ig‐positive lymphocytes were found in synovial fluid, while the remaining 9 patients had 1% or less. Appropriate control experiments indicated that the absence of membrane‐bound Ig on lymphocytes was not due to in vivo induced redistribution with subsequent endocytosis of Ig receptors. The percentages of B‐lymphocytes in peripheral blood from patients (mean 11% and range 3–19%) were not significantly different from those of 54 normal individuals (mean 10% and range 3–22%). Rosette‐forming lymphocytes were found in synovial fluid of 11 patients studied, with mean 29.6% and range 19.0–60.2%, which are significantly higher than the corresponding values in peripheral blood, 22.7% and 0.9–41.1%. The latter values were also significantly higher than those of peripheral blood from 32 normals (mean 14.8% and range 0.9–34.7%). The increased proportions of T‐lymphocytes in synovial fluid in rheumatoid arthritis in contrast to the absence or very low numbers of B‐lymphocytes may indicate an important role for the former in the pathogenesis of rheumatoid inflammation.
The clinical and pathological findings in a 6-month-old boy with III-IV pharyngeal puoch syndrome are reported. The infant had multiple congenital anomalies including absence of the parathyroid glands, maldescent of the thymus, aberrant right subclavian artery and dysfunction of the glossopharyngeal nerve. Because of persistence of the thymus in the cervical area, a thymic shadow was not found on roentgenographic examination of the anterior mediastinum. The weight and histology of the thymus were normal, as were studies of humoral and cellular immunity.
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