Bf allele frequencies were studied in a sample of the normal Spanish population and in family haplotypes. BfF1 shows a frequency higher than in other Caucasoid populations and closer to that found in Negroids. Basques show an even higher BfF1 frequency. BfF1 is in strong linkage disequilibrium with B18. HLA‐Bw44 is found to be the B12 split in linkage disequilibrium with BfF and Bw50‐BfS1 association is confirmed. DR3‐BfF1 are not in linkage disequilibrium in the normal Spanish population, in contrast to DR3‐BfF1 linkage found in a diabetic Spanish population.
Results are discussed on the bases of the paleo‐North African Iberian population origins and of the use of Bf to define B12 and Bw21 splits.
HLA-A, HLA-B, HLA-C, HLA-Bw4, Bw6 and HLA-DR antigens have been detected on purified seminal cells than spermatozoa (SCnonSz) using specific absorptions. These results contrast with those obtained on spermatozoa, which only express significant amounts of HLA-A and HLA-B antigens, and which may be relevant to explain immunosuppressive alloimmunization in the acquired immunodeficiency syndrome (AIDS).
HLA‐A and ‐B antigens have been found in purified spermatozoa using a double fluorescence cytotoxicity tecnique and specific absorptions. HLA‐C, ‐Bw4, Bw6 and ‐DR antigens have not been found using the same techniques. Controversial results regarding HLA expression on spermatozoa have been presumably obtained because of a lack of both seminal cell purification and an appropriate more accurate cytotixicity technique. The presence of HLA antigens on seminal cells may be of relevance to explain the postulated immunosuppressive alloimmunization which may occur in the acquired immunodeficiency syndrome (AIDS).
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