SUMMARY The effects of a porcine gastric fundic mucosal extract (molecular weight <10 000) has been compared with the effects of eight candidate gastrointestinal peptides on glucose absorption from the jejunum in a rat model. Bolus injection of the extract produced immediate and marked depression of glucose absorption. None of the candidate peptides tested produced this response, although somatostatin and substance P depressed absorption as a late phenomenon after 30 minutes. We conclude that the effects of the fundic extract are not reproduced by any of these candidate peptides. This strengthens the evidence for a novel gastrointestinal peptide, resident in fundic mucosa, which affects absorption from upper small bowel.There is evidence for a peptide factor, secreted from gastric fundic mucosa, which affects jejunal mucosal absorption. 1-4 Stimulation of gastric fundic mucosa by distension or raised pH significantly reduced luminal loss of glucose, 14C-labelled 3-0-methyl glucose and tracer ions 22Na and 99mTc, from the jejunum. An extract of porcine gastric mucosa also reduced jejunal absorption when infused intravenously in a rat model.4Samples of the porcine gastric fundic mucosal extract contained only small and variable amounts of some of the known gastrointestinal peptides (Bloom, personal communication; Table 1). The present series of experiments was designed to see if the effects of the fundic extract on jejunal absorption could be because of the action of a specific candidate gastrointestinal peptide.
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