A series of 1,2,4-triazole-3-carboxamides have been prepared from 1,2,4-triazole-3-carboxylates under mild conditions. Efficient synthesis of amides directly from esters and amines is achieved under mild, neutral conditions with liberation of alcohol as by-product. Both primary and secondary aliphatic and aromatic amines can be utilized. This unprecedented, general, environmentally benign reaction proceeds in toluene under microwave conditions. The newly synthesized compounds were characterized by spectral and elemental analyses.
Efficient One-Pot Selective Reduction of Esters in β-Ketoesters Using LiHMDS and Lithium Aluminum Hydride. -With exception of bulky substrate (IIIb), aromatic β-ketoesters are selectively converted into the corresponding β-hydroxy ketones following the sequence A) and B). In the case of aliphatic substrates, both the ester and the ketone are reduced. -(SIVAGURUNATHAN, K.; KAMIL, S. R. M.; SHAFI, S. S.; KHAN, F. L. A.; RAGAVAN*, R. V.; Tetrahedron Lett. 52 (2011) 11, 1205-1207, http://dx.
Chitosan and it’s derivatives has varity of advantages likes in industrial and biomedical fields. In recent years,research has been focused on biodegradable films of natural polymers like chitosan,starch,cellulose and etc. Such polymers may be proteins of plant and biological materials. Natural biopolymeric films with tridaxprocumben have potential advantage over the synthetic products since they are totally biodegradable from biological materials. Tridaxprocumbens extract is used for wounds healing as anticoagulant, antifungal and insect repellen. It is well known for application to treat infection and skin diseases in folk medicines,etc. The present study was focused on impregnation of tridax-procumbens extract into chitosan to develop a antimicrobial films. Further, they assessed was for physicochemical properties through x-ray diffraction and flourier transform infrared(FTIR) spectroscopy studies and antimicrobial activity.
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