SARS-CoV-2/COVID-19 und neuromuskuläre ErkrankungenBestandsaufnahme der DGN (Deutsche Gesellschaft für Neurologie) Kommission Motoneuron-und neuromuskuläre ErkrankungenIn dieser Bestandsaufnahme werden das aktuell publizierte Wissen zu den primären Auswirkungen einer SARS-CoV-2-Infektion/COVID-19-Erkrankung auf das periphere Nervensystem und die Muskulatur sowie zu den sekundären Verschlechterungen präexistenter neuromuskulärer Erkrankungen durch eine SARS-CoV-2-/COVID-19-Erkrankung zusammengefasst und Empfehlungen daraus abgeleitet.
Infektion mit SARS-CoV-2 als neuromuskuläre PrimäraffektionHäufig fragen Patient*innen mit einer neuromuskulären Erkrankung ihre behandelnden Ärzt*innen nach dem persönli-
Background
We present one patient with an initial diagnosis of Guillain‐Barré syndrome (GBS) and one with Charcot–Marie–Tooth disease (CMT) type 1A.
Methods
Both patients underwent ankle tibial nerve fusion‐imaging of high‐resolution ultrasound (HRUS) with 7T MR neurography (MRN).
Results
In GBS, the nerve was enlarged, T2‐hyperintense, and showed increased vascularization 21 months after symptom onset. In CMT1A, the enlarged nerve was T2‐isointense with normal endoneurial blood flow.
Conclusions
We demonstrate the utility of 7T‐MRN‐HRUS‐fusion‐imaging. In GBS, there was evidence of ongoing inflammation resulting in a changed diagnosis to acute‐onset chronic demyelinating polyradiculoneuropathy and maintenance of immunotherapy. By MRN‐HRUS‐fusion, patients with presumed peripheral axonal degeneration could be shown to display imaging markers associated with peripheral nervous system inflammation. Thus, more accurate identification of a treatable inflammatory component may become possible.
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