variants were found mostly as pure variants. With a median follow up of 6.5 years, patients who harbored pure variant were found at multivariablean alyses with lower survival outcomes when compared with pure urothelial carcinoma (all p<0.01). Conversely no differences were found between mixed variant vs. pure urothelial at multivariable Cox regression analyses predicting recurrence, CSM and OM (all p>0.1).CONCLUSIONS: Presence of histologic variants at RC is a common finding accounting for approximately 30% of specimens. In this setting, the presence of a pure variant but not the presence of mixed variant with urothelial carcinoma is related to a detrimental effect on survival outcomes after RC.
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