A novel homologous series of 1-N-L-tryptophanglycerol-ether surfactants was synthesized and characterized. The precursor compounds, 3-alkyloxy-1-chloropropan-2-ols, were prepared from epichlorohydrin and aliphatic alcohols with alkyl chain lengths of 9-16 carbon atoms. Tryptophan was then attached to the monosubstituted glycerol backbone from its αamino group through an α-NH-C bond. Structural assignment of the new compounds was made on the basis of elemental analysis and spectroscopic data. Critical micelle concentrations of the new surfactants, as well as the negative logs of the surfactant concentrations required to reduce the surface tension of the solvent by 20 mN/m (pC 20 ) and the interfacial areas occupied by the surfactant molecules, were calculated from aqueous surface tension measurements using the Wilhelmy plate technique.
A novel homologous series of 1-N-L-phenylalanine-glycerol ether surfactants was synthesized in satisfactory yields via reaction of epichlorohydrin with aliphatic alcohols with alkyl chains of 10-15 carbon atoms. Structural assignment of the new compounds was made on the basis of elemental analysis and spectroscopic data. Critical micelle concentration (CMC), surface tension at the CMC (γ CMC ), surfactant concentration required to reduce the surface tension of the solvent by 20 mN/m (pC 20 ), and the interfacial area occupied by the surfactant molecules (A min ) were determined from aqueous surface tension measurements using the Wilhelmy plate technique.
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