Experimental research was conducted on the study of the relationship of the general toxic and gonadotoxic effects of cadmium and boron under conditions of subacute and chronic oral intoxication on white random-bred rats, by use of biochemical, physiological, cytological, and pathomorphological methods. It is shown that the gonadotoxic effect of cadmium is manifested on the same level (3 mg/kg of body weight) as the general toxic effect. The gonadotoxic effect of boron is dominant and is manifested at a lower level (6 mg/kg of body weight) than the general toxic effect (20 mg/kg). On the basis of the results of chronic experiments, 0.001 mg/l. is recommended as the hygienic standard for cadmium in water and 0.5 mg/l. for boron.In recent years, evidence has accumulated in the literature on the gonadotropic effect of cadmium and boron (1-7). In earlier studies conducted in the U.S.S.R., the hygienic standards for the content of these substances in water were established without consideration of their effect on gonad function.For this reason, we have set for ourselves the task of making the threshold and nonactive levels of these compounds in water more precise while taking into consideration their effect on the functional state of the organism and the state and function of the gonads.In addition to a general toxic effect, a gonadotropic effect was determined for a cadmium dose of 1-4 mg/kg of weight, depending on the species of animal, in recalculating to ions of the metal and for a dose of 6 mg/kg in the case of boron under conditions of subacute oral cadmium chloride and boric acid intoxication for an average period ranging from 21 to 35 days. The general toxic effect of cadmium was shown by the reduction of peroxidase and blood cholinesterase activity and in the reduction of the sulfhydryl group count in the blood serum of experimental animals. The general toxic effect of boron was shown by the reduced activity of the aldolase of blood serum. The gonadotropic effect of both metals was observed in subacute experiments based on changes in the function and histostructure of the gonads. Thus the histological analysis of the gonads in the case of cadmium intoxication made it possible to explain the intensification of desquamation and the disorganization of the spermatogenic epithelium, hypertrophy and the proliferation of Sertoli cells, thickening of basal membranes, swelling of arteriolar walls and reduction of the arteriolar lumen, expansion and congestion of the capillary network, formation of a transudate, and the appearance of multinuclear giant cells in the lumen of the spematic cords as a result of the disturbance of endomytosis for the effect level of the metal. Total
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