HighlightsLesser sac pathological entities are uncommon.A 62 year old male, cancer presented with progressive abdominal distension.Examination revealed a midline intra abdominal mass in the epigastrium and umbilical region.Radiological investigations were suggestive of a retroperitoneal tumor.Surgical exploration confirmed a large multi lobulated tumor arising primarily from the lesser sac.Post operative histopathological examination confirmed a myxoid liposarcoma.A literature review of primary lesser sac tumors with particular reference to myxoid liposarcoma is presented.The myxoid variant is unique for its peculiar biological behavior, in its sensitivity to chemotherapy and radiotherapy and for the presence of specific cytogenetic marker.
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