Introduction: Deoxyribonucleic acid (DNA) extraction is a fundamental step in any forensic analysis procedure. Selecting an extraction method to yield DNA is suitable in quality and quantity is, also, crucial. Aim: The objective of this study is to evaluate the adequateness of two DNA extraction methods regarding the DNA quality & quantity, and the time & money costs. Materials & Methods: The first method is the organic phenol extraction method, while the second is the automated magnetic beads extraction technology. The DNA quality and quantity were assessed by the NanoDrop ND-1000 spectrophotometer. Results: Organic phenol extraction, significantly, yielded more DNA in quantity than the magnetic beads methods. However, non-significant difference was detected in the quality of the DNA yielded from the two methods as measured by NanoDrop ND-1000 spectrophotometer. Organic phenol extraction consumed far more time but much less money than the magnetic beads method. Conclusion: Accordingly, magnetic beads technology is more efficient DNA extraction method than organic phenol extraction in saving time, effort and lab safety. On the other hand, organic phenol extraction is more economic and efficient in the quantity of the DNA yielded. However, both methods yielded the same quality of the extracted DNA. Automation saves much time than manual techniques.
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