Vol. 64 oxide, oxygen, benzyl chloride, ethyl acetate and acetyl chloride with benzyhnagnesium chloride on a larger scale has confirmed the results of previous investigators. Only acetyl chloride gave rearrangement.
Some interest has been evidenced in open-chain analogs of the successful analgesic Demerol (1). Our work was directed toward the preparation of several a-phenyl-a-ethyl-y-substituted butyronitriles and butyrates. Varying analgesic and anticonvulsant activity has been reported for a number of gamma-amino compounds of this class (2) but little work has been done on the / -ethyl compounds.
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