The anti-inflammatory activity of aerial roots of Ficus benghalensis was evaluated by using carrageenan induced paw oedema and cotton pellets induced granuloma in rats. The study was carried out by using 100 and 200 mg/kg doses of the aqueous extract of aerial roots of Ficus benghalensis. The preliminary pharmacological screening of the extract of aerial roots of Ficus benghalensis showed significant dose dependent anti-inflammatory profile.
The present study was undertaken to evaluate the cardiotonic activity of the aqueous extract of leaves of Vitex negundo Linn. The leaves are believed to contain some antioxidants and hence pose it to be used in the prevention of cardiovascular diseases. The cardiotonic effect of aqueous extract of leaves of V. negundo Linn. was studied by using isolated frog heart perfusion technique (IFHP). Ringer solution without calcium was used as a vehicle for administration of aqueous extract as test and digoxin as standard. A significant increase in the height of force of contraction (positive ionotropic effect) and decrease in heart rate (negative chronotropic effect) was observed at smaller doses (0.4 mg). The effect increased as dose was increased. The test extract had not produced cardiac arrest even at a dose of 2 mg, a higher concentration as compared to standard, digoxin that showed cardiac arrest at dose of 0.2 mg. Hence, as compared to standard, test drug showed wide therapeutic index.
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