In this confirmatory study, we tested if a calculation that included the non-uniformity of dose deposition through a voxel-based dosimetric variable Ψ was able to improve the dose–response agreement with respect to the mean absorbed dose D. We performed dosimetry with 99mTc-MAA SPECT/CT and 90Y-PET/CT in 86 patients treated 8 instead of 4 days after the reference date with 2.8 times more 90Y glass microspheres/GBq than in our previous study. The lesion-by-lesion response was assessed with the mRECIST method and with an experimental densitometric criterion. A total of 106 lesions were studied. Considering Ψ as a prognostic response marker, having no Ψ provided a significantly higher AUC than D. The correlation, t-test, and AUC values were statistically significant only with the densitometric method and only with post-therapy dosimetry. In comparison with our previous study, the dose–response correlation and AUC values were poorer (maximum r = 0.43, R2 = 0.14, maximal AUC = 0.71), and the efficacy at a high dose did not reach 100%. The expected advantages of voxel dosimetry were nullified by the correlation between any Ψ and D due to the limited image spatial resolution. The lower AUC and efficacy may be explained by the mega-clustering effect triggered by the higher number of microspheres/GBq injected on day 8.
Aim of this work is evaluate the performance of LiF detectors, TLD-100H, used for both environmental and radiodiagnostic dosimetry. General-Order kinetics (GOK) expressions were applied to experimental glow curves of TLDs 100H (LiF. Mg, P, Cu), that were irradiated with an X-ray tube at 140 kVp and reading with a Riso TL/OSL-DA-10 system. New tests were introduced such as the Recuperation test, for evaluate the residual luminescent after each measurement cycle, the Recycling test, aimed to evaluate any systematic errors in the calibration curve and, at last, the Recovery test, with the purpose of evaluate the accuracy of the measured dose from each single dosimeter. The results obtained show an accuracy on the various measured doses ranging from 1.20% to 2.56%.
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