Three cases of periosteal ganglia of long bones are presented. These lesions are produced by mucoid degeneration and cyst formation of the periosteum to produce external cortical erosion and reactive periosteal new bone. They are not associated with a soft tissue ganglion or an intraosseous lesion. They may radiologically mimic other periosteal lesions or soft tissue neoplasms which erode bone.
A 3.5-year-old boy with a multifocal primary lymphoma of the brain was treated successfully without neurotoxicity with a treatment regimen fhat did not include radiation. The protocol of Dexacort (dexamethasone), methotrexate, Oncovin (vincristine), and BCNU (carmustine) (DEMOB), which was developed with the use of MTX pharmocokinetic studies, was given over 7.5 months, and resulted in tumor disappearance on computerized tomography scans and marked improvement in clinical status. The patient remains in good health 3 years after diagnosis (March 1985).Cancer 57:6-11,1986.HE REALIZATION in the Iast few years that microgly-T omas are primary brain lymphomas' raised the hope that, with appropriate antilymphoma therapy, cure could be achieved. We report the first case that, to the best of o u r knowledge, has been treated successfully without radiotherapy. It has been 3 years since diagnosis and 30 months since therapy was completed.
Case ReportA 3.5-year-old boy was referred for postoperative treatment of a primary brain tumor in January 1982 from the Neurosurgical Department of this hospital. He had been healthy until August 198 1, when he had an episode of vomiting and a 2-hour loss of consciousness. One week later he had a similar attack. Computerized tomography (CT) (Figs. 1A and IB) showed two foci; one in the left frontoparietal area and the other in the left temporo-occipital area. The frontoparietal focus was not visualized on a further CT 6 weeks later, but the temporo-occipital lesion had grown in size (Fig. 2).He experienced weakness of his left leg and arm and, after a further episode of vomiting and headache, underwent craniotomy with gross resection of the left temporal lesion (December 2 1, I98 I). The tumor was removed piecemeal. The internal border was less clearly demarcated than the superficial border, but no obvious tumor remained after the operation.
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