The Effect of Paracetamol mechanism by which it works, metabolism, recommended doses, toxic dosage are discussed with study reports in this paper. Paracetamol shows some life threatening effects like Liver damage which in turn leads to live failure and death. Though it reduces fever and pain, it is found highly toxic. The mechanism by which Paracetamol reduces fever and pain is still not known. On metabolism, Paracetamol is converted to a metabolite which is very toxic to liver cells. In recommended doses (1-2 g/day), Paracetamol does not irritate stomach lining, kidney cells and liver cells. Studies reported that high dosage (>2 g/day), resulted in Gastrointestinal complications, abnormal Kidney function, Liver damage.
Lectins, multivalent cell-agglutinating proteins, by virtue of their exquisite sugar specificities are useful tools in widespread biomedical applications. The present investigation was carried out to study the physico-chemical characteristics of the hemolymph hemagglutinin of the marine crab Grapsus albolineatus. The specificity of agglutinin to erythrocytes, sugars, glycoproteins, pH, temperature and the effects of divalent cations and calcium chelators was determined. A naturally occurring hemagglutinin with high HA titer of 2048 with rat erythrocytes was identified in the hemolymph of the marine crab G. albolineatus. The HA activity was stable between pH 7 and 9 and showed thermal stability between 0˚ and 40˚C. The hemolymph agglutinin was calcium dependent and HA activity was reduced when exposed to calcium chelators such as EDTA and trisodium citrate. Hemagglutination inhibition assay exhibited the strongest binding specificity towards the sugars GalNAc, GlcNAc and glycoprotein fetuin. The cross-adsorption assay revealed that the hemolymph of the marine crab Grapsus albolineatus possesses single agglutinin.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.