The aim of this study was to explore changes in the correlational association between predictors (i.e. sociodemographics, subjective health, social support, anxiety and coping) and outcome measures (i.e. subjective wellbeing and autonomy) before and after rehabilitation treatment. The data came from a sample of 90 patients (mean age 78.8 years; 84 percent female; 37 percent stroke, 44 percent fracture, 19 percent other diagnoses), who were assessed before and after rehabilitative treatment. Results revealed that although changes between predictors and outcomes were not prevalent with respect to subjective wellbeing, they were clearly evident with respect to autonomy. Whereas psychological variables, such as state anxiety and behavioural coping, played no predictive role at entry, they became the strongest predictors of autonomy at discharge.
This study considers findings of psychological gerontology as particularly important for geriatric rehabilitation research. Its concrete aim was to describe the course and outcome of geriatric rehabilitation based on a wide range of success criteria, to explore the influencing role of age, sex, and diagnosis as well as to describe the variability pattern of success. The data were gathered from a sample of 100 older adults who underwent treatment in a German inpatient rehabilitation unit. Participants were assessed across five measurement occasions by use of a state-of-the-art geriatric assessment and a psychological data collection part. The results underline, for one, that significant improvements of functional as well as psychological capacity were obtained. Second, age and sex played practically no role concerning the course of the success criteria, whereas diagnosis revealed some statistically meaningful effects. Third, it was found that the variability of success was characterized by a relatively homogeneous pattern of gain with regard to functional criteria; with respect to psychological variables, heterogeneity was more pronounced and some participants show loss as well, a chance for further improvement of the geriatric rehabilitation.
Human T lymphocytes were shown to proliferate in response to tetanus toxoid antigen only in the presence of macrophages. This response was inhibited by anti-DRw but not by anti-lILA (A and B loci) antisera added to the cultures and by pretreatment of macrophages but not of T cells with antiDRw antisera and complement. Macrophages pulsed for 18 hr with antigen and then washed were capable of triggering T-cell proliferation. Addition of anti-DRw but not anti-HLA (A and B loci) antisera during the pulse period inhibited the macrophages' ability to trigger T-cell proliferation. The data obtained indicate that human T cells recognize and proliferate in response to antigen presented by the macrophages in association with Ia-like antigens.It has been shown in experimental animals that T lymphocytes respond to antigens only in the presence of macrophage-like accessory cells and that native antigen alone is insufficient to cause T-cell activation (1). In addition, many recent studies have shown that T-cell recognition of antigen presented by accessory cells involves recognition of major histocompatibility complex antigens-namely, the Ia antigens in the guinea pig and the IA and IE/IC subantigens in the mouse (2, 3).The present studies were designed to study human macrophage-T-cell interaction in the proliferative response to the soluble antigen, tetanus toxoid (TT). The data presented indicate that this response has an absolute requirement for macrophage (M+) atd is inhibited by anti-DRw but not anti-HLA antisera and that the inhibitory effect of anti-DRw antisera is exerted at the level of the Mo.MATERIALS AND METHODS Antigen. TT was obtained from the Massachusetts Biological Laboratories (Lot LP43OPM) and dialyzed extensively against 0.15 M NaCi.Antisera and Tissue Typing. Anti-HLA antisera (A, B, C, and DRw loci) were obtained from multiparous women whose informed consent was obtained. The antibody specificity of the antisera was determined by testing against panels of typed lymphocytes (4). These antisera were cytotoxic to lymphocytes at a final dilution of 1:4 in the microcytotoxicity assay. The anti-HLA-A,B antisera used in the cell culture experiments were shown to have no DRw reactivity, because after exhaustive absorption (three cycles) with pooled platelets they showed no reactivity with a panel of purified B lymphocytes. HLA-ABC activity was removed from anti-HLA DRw antisera by absorption with random pools of platelets (5). Anti-DRw antisera were cytotoxic to B cells at a final dilution of 1:4 in a microcytotoxicity assay.HLA typing was performed on Ficoll/Hypaque isolated lymphocytes by microcytotoxicity assay as described (4)
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.