International audienceAn efficient simulation tool is developed to generate realistic X-ray CT images, including a good modeling of physics and a very detailed anthropomorphic model in a reasonable computing time. This simulation tool consists in a coupling of the existing X-ray radiographic simulation software SINDBAD with the extended NURBS-Based Cardiac-Torso (XCAT) phantom. Both primary and scatter contributions in X-ray CT projections are calculated thanks to a combination of analytical and Monte Carlo approaches. The representation of the XCAT phantom is adapted to the level of resolution required by the primary and scatter images. We present in this paper first X-ray CT projection data which are simulated under an angiography configuration. Although the XCAT phantom is complex, the computation time is reasonable, even with the estimation of the scatter radiation. In future studies, similar simulations will be performed in real clinical CT scanner conditions, with an accurate modelling of detectors and a finer representation of the XCAT phantom, and will be compared with real X-rays CT images for validation
International audienceRespiratory motion in Positron Emission Tomography leads to reduced image quality, influencing this way the quantitative accuracy of PET measurements, as shown in numerous studies. However, only few results have been published on its impact on lesion detection. This study intends to evaluate the impact of motion correction on the detection of small lesions (between 8 and 12 mm diameter) using a Computed-Aided Detection (CAD) system on FDG whole-body simulated PET images. We evaluate two types of motion correction techniques, both using motion fields derived from the reconstruction of gated PET images. The first technique consists in averaging the coregistered gated reconstructed PET images, while the second method integrates the motion fields during the iterative reconstruction process. (c) 2010 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works
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