Background: Children with Unilateral Cerebral Palsy (UCP) usually have obvious impairment of hand function and limited active supination, which causes restrictions of upper extremity functions. Objective: This aimed to compare between Kinesiotaping and wrist wheel effect on forearm supination range of motion and its reflection on functions of upper limb in children with UCP. Patients and Methods: Forty-eight children with UCP their age from 6 to 8 years were divided randomly into 2 groups with twenty-four in each, Kinesiotaping (KT) and Wrist Wheel (WW). KT group children were treated by a designed physical therapy program after forearm Kinesiotaping application, while children in WW group were treated by the same designed physical therapy program while using wrist wheel. Treatment program was conducted for three successive months at frequency of 3 sessions per week. Before the commencement and after the study completion forearm supination range of motion was measured using digital goniometer and Shriners Hospital Upper Extremity scale was used to evaluate upper extremity functions in the affected upper limb. Results: A statistically significant change was observed in each group after treatment application when comparing before and post treatment mean values (P < 0.001). Also, a statistically significant change was noticed when comparing after treatment results between both groups in favor to wrist wheel group. Conclusion: Both Kinesiotaping and Wrist Wheel can improve supination ROM and upper extremity functions of children with UCP, with more effectiveness to Wrist Wheel.