The aim of this study was to investigate the possible relationship between variations in local skin and body temperatures, and a subcutaneous hyperaemia response during sleep in humans. Nocturnal subcutaneous blood flow (SBF) was measured in the lower legs of 9 subjects for 8-12 h under outpatient conditions. The core temperature was measured by a tympanic membrane temperature sensor, and the local skin temperature was measured by a skin temperature sensor. The 133Xe wash-out technique with portable CdTe(Cl) detectors was used for measurement of the SBF. The SBF increased significantly (P < 0.0001) after 1 h sleep, with the hyperaemia persisting for 2 h. During the hyperaemic phase, the local skin temperature increased significantly (P < 0.0001) and then decreased again in the post-hyperaemic phase (P < 0.01). The core temperature decreased significantly during the measurement period (P < 0.01). Separate ordinary linear regression analyses revealed no significant correlations between the measured temperature parameters and the blood flow levels during sleep. The results indicate no governing role of the local skin or body temperatures on the local SBF. The local skin temperature increased significantly secondary to the nocturnal subcutaneous hyperaemia (i.e. active vasodilatation), which is believed to be involved in a thermoregulatory effector mechanism.
of the following factors, as well as others, perhaps, which are yet unknown or unrecognized.Relief of Hypoxia.-In chronic pulmonary dysfunction the fundamental result of bronchial obstruction due to spasm and/or retained secretions, of diminished expansion of the chest or lungs, and of alveolocapillary block, when this is present, is a diminished amount of oxygen delivered to, or absorbed from, the alveoli. Since structural and functional changes in the diseased portions of the lungs secondarily induce functional derangement in the healthy lung tissue, all the alveoli are affected either primarily or secondarily, and hypoxia must be widespread. The degree of impaired function is probably not the same for all alveoli because of local differences in the degree of spasm, obstruction, expansion, and alveolocapillary block; consequently, there are also varying degrees of hypoxia. Oxygen is given at high concentration to insure its adequate supply. The gentle positive pressure of 4 cm. H20 is believed to enhance its distribution
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