1948 63 were analyzed mass-spectrometrically and found to contain not more than 0.5% of impurities. The results from the analysis of these mixtures, using the two procedures described above, are presented in Table I, which shows that the method yields accurate values over a wide range of concentrations.
A simple, accurate, precise RP-HPLC method has been developed and validated for the simultaneous estimation of Bromhexine HCl and Enrofloxacin in their combined tablet dosage form. The combination used for the Separation is ENROLIQ-B. Separation was performed on a C18 column [Hypersil BDS C18 column, 250 x 4.6 mm], with 0.05 M KH2PO4 Buffer pH 6: Methanol: Triethylamine (70:30:0.1 %v/v/v) as a mobile phase and flow rate was kept at 1 ml/min. Good sensitivity was found with UV detection at 261.00 nm. After method development the interference with the active compounds and excipients, repeatability and linearity were investigated. ReBROMtion times were found to be 3.190 and 5.067 min. respectively, for BROM and ENR. The method was validated over the analytical range from 1.5-4.5μg/ml for BROM (r 2 =0.998) and 20-60 μg/ml for ENR (r 2 =0.999). This method showed good reproducibility and recovery with %RSD in the desired range. The proposed method can be successfully applied for the routine analysis of both drugs in their combine dosage form.
Degumming of soybean oil considerably reduces the free fatty acid (FFA) content of the oil. Lowering of refining loss when oil is degummed prior to caustic treatment is attributed to this reduction in FFA and the excess carry over of neutral oil, because gums are excellent emulsifiers. Pretreatment of solvent extracted soybean oil with phosphoric acid followed by water degumming and caustic refining results in a lower refining loss and considerable reduction in caustic requirement in comparison to the conventional process based on water degumming followed by gum conditioning with phosphoric acid and caustic refining. The process gives sharp and fast separation of gums from the oil.
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