Personalised cardiac models were built from the computed tomography imaging data for two patients with implanted cardiac resynchronisation therapy devices. The cardiac models comprised a biventricular model of myocardial electrophysiology coupled with a model of the torso to simulate the body surface potential map. The models were verified against electrocardiogams (ECG) recorded in the patients from 240 leads on the body surface under left ventricular pacing. The simulated ECG demonstrated a significant sensitivity to the myocardial anisotropy and location of the pacing electrode tip in the models. An apicobasal cellular heterogeneity was shown to be less significant for the ECG pattern at the pacedventricle activation than that showed earlier by Keller and co-authors (2012) for the normal activation sequence.
В данной работе были построены две персонифицированные модели электрофизиологии сердца и торса человека c активацией из точечного источника. Модели верефицированы на клинических данных пациентов. Построенные модели использовались для исследования влияния различных физиологических особенностей миокарда на электрокардиограмму. Помимо этого, было найдена оптимальная позиция расположения стимулирующего электрода для наиболее быстрого возбуждения двух желудочков целиком.
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