The prevalence of hypertension was investigated in a systematically chosen sample of patients attending a diabetic clinic. One hundred ninety-one patients were classified as Type 1 (insulin-dependent), 183 were classified as Type 2 (non-insulin-dependent) and 12 were deemed unclassifiable. Two hundred fifty-five control subjects attending non-medical out-patient clinics were also examined under similar conditions. Hypertension was significantly (p less than 0.001) more common among Type 2 patients (38%) than among Type 1 patients (15%) or control subjects (16%). The difference between Type 2 patients and control subjects, but not between Type 2 and Type 1 patients, persisted when the influences of age and body mass index were controlled. We also investigated the prevalence of hypertension among the siblings of the hypertensive patients identified, together with a matched normotensive group. One hundred eighty-eight siblings were examined and historical details were obtained for a further 451 siblings. When age and body mass index were controlled for in examined siblings, the risk of hypertension was greater in those with a hypertensive proband than in those with a normotensive proband, in the control (p less than 0.06) and Type 1 (p less than 0.02) groups.(ABSTRACT TRUNCATED AT 250 WORDS)
We reviewed the relative incidence of histological sub-types of thyroid carcinoma at St. Vincent's Hospital between 1970 and 98 Vol. 162 No. 3 1991 and compared survival rates. The findings were compared with previous reports between 1946 and 1970.Patients with thyroid carcinoma from 1970 through 1991 were identified and pathological and clinical data retrieved.Of 141 patients identified, 113 were female and 28 male. Fiftyseven patients had papillary, 41 follicular, 24 anaplastic and 6 medullary carcinoma. There were 10 lymphomas and 3 thryoid metastases. The 10-year actuarial disease-free survival for papinary carcinoma was 93%, follicular 80% and medullary 37%. The median overall survival for anaplastic carcinoma was 5 months. The number of cases seen increased from 2.2 per year between 1946 -1965 to 7.6 per year between 1982-1991 . From 1946to 1991 the relative incidence of papillary carcinoma increased from 19% to 57%.Of interest is the change in relative incidence of the histological sub-types. Follicular carcinoma is associated with endemic goitre and increased iodine intake may explain its reduced incidence. Increased radiation may explain the increase in papillary carcinoma. There is a need for a National Tumour Registry to see if this local trend is reflected nationally.
PROTEOLYTIC ENZYMES AS PROGNOSTIC MARKERS IN BREAST CANCER
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.