No abstract

A regime map of granule growth behavior is proposed based on granule deformation during collision and the granule liquid content measured as the maximum pore saturation. The granule deformability on collision is represented by a deformation number, which is a ratio of granule impact energy to the plastic energy absorbed per unit strain. Granule growth regimes such as steady growth, induction, nucleation, crumb, and sluny are defined. This regime map qualitatively explains the uariatiom in granulation behauior. Laboratoly drum granulation experiments were used to test the regime map. Experiments were peqformed in a 0.3-m-dia. drum using three sizes of glass ballotini (19, 31, and 60 pm) with water and glycerol as liquid binders. Increasing granule yield stress by decreasing particle size and increasing binder uiscosity caused the system to move from steady growth to induction behauior as predicted by the regime map. Preliminary ualidation with literature data was also encouraging. More work, howeuer, is required to better quantify the boundaries between different growth regimes and to investigate the effect of process agitation intensiq. This regime map has great potential to help design and control granulation systems, because it is based on properties of the powder/binder qstem that can be measured or estimated without peqforming any granulation tests.

No abstract

In this work, the coalescence of deformable granules in wet granulation

No abstract