Virtual poster abstractsbetween neonates with normal and abnormal neurodevelopmental outcomes. Then, several candidate proteins were validated with enzyme-linked immunosorbent assays (ELISA). Results: A total of 20 neonates of MCMA twins were included and the incidence of abnormal neurodevelopmental outcome was 25%. In the proteomic profiling, 18 proteins were differentially expressed between two groups. The up-regulated proteins in the neonates with adverse neurodevelopmental outcome were Ig-γ-4 chain C region, Apolipoprotein E and Alpha-fetoprotein. In contrast, Ig-λ-chain V region 4A, Ig heavy variable 3, Ig-κ-chain C region, Ig-μ-chain C region, C1q, Ceruloplasmin, Ig-λ-chain V-I region were decreased. In the validation experiment with ELISA of proteins, cord blood concentration of Ceruloplasmin was significantly lower in neonates with adverse neurodevelopmental outcome than those without. Conclusions: We identified proteomic biomarkers in cord blood associated with adverse neurodevelopmental outcome. Ceruloplasmin could be one of useful predictive biomarkers for adverse neurodevelopmental outcome in MCMA twin.
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