The results of complex investigation performed in 117 patients with progressing psoriasis are reported below. It is estimated that in case of psoriasis progression there are evidences of an excessive accumulation of low and mean molecular substances of catabolic origin in plasma and urine that accompanies to activation of the endotoxin elimination system. The intensity of endotoxicosis syndrome is interrelated with the presence of the intestinal indigestion and the severity degree of dysbiosis. An addition of lactulose (Duphalac, Solvey-Pharma) to the complex therapy of patients with psoriasis aggravation using 25 ml of the drug solution for 21 days lead to significant improvement of the endoscopic picture in the large intestine, a reduction of endogenous intoxication severity and is accompanied by marked clinical benefit.
The endogenous intoxication syndrome manifested in the form of excessive accumulation of low and mean molar mass substances
in plasma and urine as well as increased blood plasma concentrations of malonic dialdehyde against the background
of reduced alpha-tocopherol was revealed in psoriatic patients with the concomitant hepatobiliary system pathology. Application
of Ademetionine in the dose of 800 mg per day for 15 days as a part of the complex therapy for such patients as opposed to the
patients receiving standard therapy resulted in reliable reduction in the severity of clinical manifestations of the disease and PASI
value as well as decrease in the concentration of low and mean molecular mass substances in plasma and erythrocytes, reduction
in the blood plasma malonic dialdehyde concentration and increase in alpha-tocopherol.
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