Spexin is a novel peptide that has been reported to be down regulated in obese adults and children and in normoglycemic adults following glucose ingestion. Spexin may therefore have a role in metabolic regulation. The purpose of the current study was to determine the effect of obesity and type 2 diabetes (T2DM), and the effect of glucose ingestion on circulating spexin concentration in adolescents. Boys and girls (mean age 16 years old) classified as healthy normal weight (NW, n = 22), obese (Ob, n = 10), or obese with T2DM (n = 12) completed measurements of body composition, blood pressure, cardiorespiratory fitness, and blood concentrations of glucose, insulin, and lipids. The median fasting serum spexin concentration did not differ between groups (NW: 0.35; Ob: 0.38, T2DM: 0.34 ng/mL, respectively). In 10 NW participants who completed a standard oral glucose tolerance test, spexin concentration was unchanged at 30 and 120 minutes relative to the fasting baseline. Finally, spexin was not significantly correlated with any of the body composition, fitness, or blood biochemical measurements. These data do not support the proposed role of spexin as a metabolic regulator or biomarker of glucose control in adolescents.
On two British Diabetic Association Educational Holidays, 67 children aged 6-9 years had their diabetic management analysed and hypoglycaemic episodes recorded. The average pre-camp carbohydrate prescription of the children was found to be 44 g below minimal recommended values. Hypoglycaemic episodes were more frequent in those with greater carbohydrate deficits and morning insulin doses in excess of 0.7 U/kg. The management of the young diabetic at camp should include a pre-camp analysis with appropriate adjustment of diet and insulin to minimize hypoglycaemic crises. Guideline figures are proposed for average age-related carbohydrate intake.
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