Synthesis and Monoamine Oxidase Inhibitory Activity of 3-Substituted 5H-Indeno(1,2-c)pyridazines.-A facile one-pot procedure for the synthesis of the title indenopyridazines (III) and (V) (7 examples) starting from ninhydrin ( I) is presented. All these products and therefrom derived analogues are potent, selective and reversible inhibitors of monoamine oxidase B. Qualitative structure-activity relationships are discussed. -(KNEUBUEHLER, S.; CARTA, V.; ALTOMARE, C.; CAROTTI, A.; TESTA, B.; Helv. Chim. Acta 76 (1993) 5, 1956-1963 Inst. Chim. Ther., Ec. Pharm., Univ. Lausanne, CH-1015 Lausanne, Switz.; EN)
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.