One hypothesis is that postnatal liver growth involves replication of mature hepatocytes, which have an unlimited proliferative potential. An alternative viewpoint is that only certain periportal cells can replicate extensively and that daughter cells stream slowly from the periportal to the pericentral region of the liver. The source of proliferating cells in both the normal and the regenerating liver is controversial. Some investigators favor the hypothesis that all parenchymal hepatocytes are capable of replication regardless of posiAbbreviations: BrdU, bromodeoxyuridine; fl-gal, beta-galactosidase; PCR, polymerase chain reaction; hAAT, human al antitrypsin; PBS, phosphatebuffered solution; TE, Tris-EDTA; FACS, fluorescence activated cell sorting; FDG, fluorescein-di-/%galactoside; FU, fluorescence units; EDTA, ethylene diaminetetraacetic acid; apo-VLDL-II, very low density apolioprotein II; LPS, lipopolysaccharide; uPA, urokinase plasminogen activator.From the Departments of 1Internal Medicine, 2Biochemistry and Molecular Biophysics, and 3Surgery,
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