A magnetic vortex is a curling magnetic structure realized in a ferromagnetic disk, which is a promising candidate for a memory cell for future non-volatile data-storage devices. Thus, an understanding of the stability and dynamical behaviour of the magnetic vortex is a major requirement for developing magnetic data-storage technology. Since the publication of experimental proof for the existence of a nanometre-scale core with out-of-plane magnetization in a magnetic vortex, the dynamics of vortices have been investigated intensively. However, a way to electrically control the core magnetization, which is a key for constructing a vortex-core memory, has been lacking. Here, we demonstrate the electrical switching of the core magnetization by using the current-driven resonant dynamics of the vortex; the core switching is triggered by a strong dynamic field that is produced locally by a rotational core motion at a high speed of several hundred metres per second. Efficient switching of the vortex core without magnetic-field application is achieved owing to resonance. This opens up the potentiality of a simple magnetic disk as a building block for spintronic devices such as a memory cell where the bit data is stored as the direction of the nanometre-scale core magnetization.

Epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and human epidermal growth factor receptor 2 (HER2) have been considered as potential therapeutic targets in cholangiocarcinoma, but no studies have yet clarified the clinicopathological or prognostic significance of these molecules. Immunohistochemical expression of these molecules was assessed retrospectively in 236 cases of cholangiocarcinoma, as well as associations between the expression of these molecules and clinicopathological factors or clinical outcome. The proportions of positive cases for EGFR, VEGF, and HER2 overexpression were 27.4, 53.8, and 0.9% in intrahepatic cholangiocarcinoma (IHCC), and 19.2, 59.2, and 8.5% in extrahepatic cholangiocarcinoma (EHCC), respectively. Clinicopathologically, EGFR overexpression was associated with macroscopic type (P ¼ 0.0120), lymph node metastasis (P ¼ 0.0006), tumour stage (P ¼ 0.0424), lymphatic vessel invasion (P ¼ 0.0371), and perineural invasion (P ¼ 0.0459) in EHCC, and VEGF overexpression with intrahepatic metastasis (P ¼ 0.0224) in IHCC. Multivariate analysis showed that EGFR expression was a significant prognostic factor (hazard ratio (HR), 2.67; 95% confidence interval (CI), 1.52 -4.69; P ¼ 0.0006) and also a risk factor for tumour recurrence (HR, 1.89; 95% CI, 1.05 -3.39, P ¼ 0.0335) in IHCC. These results suggest that EGFR expression is associated with tumour progression and VEGF expression may be involved in haematogenic metastasis in cholangiocarcinoma.

The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber with an active volume of 7.2× 6.1× 7.0 m3. It is installed at the CERN Neutrino Platform in a specially-constructed beam that delivers charged pions, kaons, protons, muons and electrons with momenta in the range 0.3 GeV/c to 7 GeV/c. Beam line instrumentation provides accurate momentum measurements and particle identification. The ProtoDUNE-SP detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment, and it incorporates full-size components as designed for that module. This paper describes the beam line, the time projection chamber, the photon detectors, the cosmic-ray tagger, the signal processing and particle reconstruction. It presents the first results on ProtoDUNE-SP's performance, including noise and gain measurements, dE/dx calibration for muons, protons, pions and electrons, drift electron lifetime measurements, and photon detector noise, signal sensitivity and time resolution measurements. The measured values meet or exceed the specifications for the DUNE far detector, in several cases by large margins. ProtoDUNE-SP's successful operation starting in 2018 and its production of large samples of high-quality data demonstrate the effectiveness of the single-phase far detector design.

A magnetic vortex core in a ferromagnetic circular nanodot has a resonance frequency originating from the confinement of the vortex core. By the micromagnetic simulation including the spin-transfer torque, we show that the vortex core can be resonantly excited by an ac (spin-polarized) current through the dot and that the resonance frequency can be tuned by the dot shape. The resistance measurement under the ac current successfully detects the resonance at the frequency consistent with the simulation.

Recent discoveries of large magnetoresistance in non-magnetic semiconductors have gained much attention because the size of the effect is comparable to, or even larger than, that of magnetoresistance in magnetic systems. Conventional magnetoresistance in doped semiconductors is straightforwardly explained as the effect of the Lorentz force on the carrier motion, but the reported unusually large effects imply that the underlying mechanisms have not yet been fully explored. Here we report that a simple device, based on a lightly doped silicon substrate between two metallic contacts, shows a large positive magnetoresistance of more than 1,000 per cent at room temperature (300 K) and 10,000 per cent at 25 K, for magnetic fields between 0 and 3 T. A high electric field is applied to the device, so that conduction is space-charge limited. For substrates with a charge carrier density below approximately 10(13) cm(-3), the magnetoresistance exhibits a linear dependence on the magnetic field between 3 and 9 T. We propose that the observed large magnetoresistance can be explained by quasi-neutrality breaking of the space-charge effect, where insufficient charge is present to compensate the electrons injected into the device. This introduces an electric field inhomogeneity, analogous to the situation in other semiconductors in which a large, non-saturating magnetoresistance was observed. In this regime, the motions of electrons become correlated, and thus become dependent on magnetic field. Although large positive magnetoresistance at room temperature has been achieved in metal-semiconductor hybrid devices, we have now realized it in a simpler structure and in a way different from other known magnetoresistive effects. It could be used to develop new magnetic devices from silicon, which may further advance silicon technology.

The deep underground neutrino experiment (DUNE), a 40-kton underground liquid argon time projection chamber experiment, will be sensitive to the electron-neutrino flavor component of the burst of neutrinos expected from the next Galactic core-collapse supernova. Such an observation will bring unique insight into the astrophysics of core collapse as well as into the properties of neutrinos. The general capabilities of DUNE for neutrino detection in the relevant few- to few-tens-of-MeV neutrino energy range will be described. As an example, DUNE’s ability to constrain the $$\nu _e$$ ν e spectral parameters of the neutrino burst will be considered.

The large cross-sectional aspect ratio of YBCO coated conductors leads to a large magnetization loss in an AC transverse magnetic field. In this work, the magnetization loss of a multifilamentary YBCO coated conductor was studied experimentally. A 100 mm length of striated multifilamentary YBCO coated conductor was prepared where the conductor and filaments were 10 mm wide and 0.4 mm wide, respectively. Striations in the sample were accomplished by laser ablation. The magnetization loss of this striated conductor as well as a reference non-striated conductor was measured in AC transverse magnetic fields normal to the conductor at various frequencies. The measured magnetization loss of the 100 mm striated conductor was less than 9% of the measured loss of the non-striated conductor at f = 11.3 Hz and H/Hcc = 8.8 (Hcc = Ic/πwc; Ic: critical current, wc: conductor width). Even though the coupling loss component increases the magnetization loss in the striated conductor, the AC loss reduction by striation is still apparent even at 171.0 Hz. The transverse resistance between filaments estimated by a four-probe measurement was 38 µΩ for 1 m at 80 K. The coupling length estimated using this transverse resistance is much longer than the sample length even at 171.0 Hz, suggesting that the filaments in the striated conductor are far from ‘completely coupled’ or ‘saturated’.

We experimentally demonstrate the thickness dependence of the spin current-induced ferromagnetic resonance in Ni 80 Fe 20 /nonmagnetic (Pt,Pd) bilayer thin films. The spectrum shape depends on the Ni 80 Fe 20 layer thickness, due to extrinsic excitation in addition to the spin Hall effect. Detailed analysis of the thickness dependence of the spectrum, both for Ni 80 Fe 20 and nonmagnetic layers, provides the spin Hall angle (Pt: 0:022 AE 0:004, Pd: 0:008 AE 0:002) and spin diffusion length (Pt: 1:2 AE 0:06 nm, Pd: 2:0 AE 0:09 nm). #