It is very difficult to develop the animal models in neuropharmacology due to the complexity of the human brain and the intrinsic complexity of developing a similar situation in experimental animals. Still, animal models in neuropharmacology have made a greater contribution in the drug development. Depression is the common and potentially devastating form of neuropsychiatric diseases affecting the individuals of every age across the world. Since the conventional antidepressants exhibit some adverse effects, it becomes important to develop novel antidepressants with fewer adverse effects. Several animal models were developed for the screening of the novel antidepressants preclinically. The different animal models used were initially developed on the basis of the phenotypical effects of stress, medication, injury, or genetic manipulation. In the current review, we have tried to compile diverse animal models used for the screening of the novel antidepressants.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.