Abstract:The inhibition activities of sulfonamide and sulfamate derivatives for human carbonic anhydrases have been quantitatively analyzed using DRAGON descriptors. QSAR models have been obtained through combinatorial protocol-multiple linear regression (CP-MLR) computational procedure. For the hCA I inhibition activity, a higher value of information content index of the 1-order neighborhood symmetry (IC1) and a lower value of the Moran autocorrelations, MATS2v and MATS1p, along with a lower number of sulfur atoms in a molecular structure (nRSR) is beneficial to the activity. A higher number of 5-membered rings (nR05), a bigger distance between nitrogen and sulfur T(N..S), and a higher value of van der Waals volume weighted descriptor (GATS6v), are helpful to improve the hCA II inhibition activity. For the inhibition of hpCA, a lower value of the descriptors Jhetv and PW5, and higher values of the eigenvalue sum from Z weighted distance matrix, SEigZ, the Moran autocorrelation of lag 8 weighted by atomic van der Waals volumes, MATS8v and the Moran autocorrelation of lag 4 weighted by atomic Sanderson electronegativities, MATS4e are favorable. The derived significant models in such descriptors may further be used to synthesize new potential compounds and to decipher the mode of their actions at molecular level.
Water is a most precious natural resource and vitally important for agricultural development and day-today living. In order to use such a precious natural resource economically, drip irrigation would be a possible solution which minimizes the losses of water and fertilizer as well as increase the yield of crops. The present study was conducted in four panchayat samities (out of six) in Bikaner district of Rajasthan on the basis of highest area and large number of beneficiary farmers under drip irrigation system. From the selected four panchayat samities, a total of 234 respondent farmers having drip irrigation system were selected randomly for the study purpose. The data were collected by personal interview method with the help of interview schedule. The collected data were classified, tabulated and statistically analyzed. The findings revealed that majority of the respondents (64.53%) were in middle age group, belonging to other backward and general caste (85.47%), agriculture work as their main occupation (72.22%), educated can read and write up to primary and middle levels (55.99%), member of one or more organizations (56.84%), having medium land holding
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