The coronavirus disease 2019 (COVID-19), is a highly contagious transmittable disease caused by a recently discovered coronavirus, pathogenic SARS-CoV-2. Followed by the emergence of highly pathogenic coronaviruses in 2003 SARS-CoV, in 2012 MERS-CoV, now in 2019 pathogenic SARS-CoV-2, is associated with a global “pandemic” situation. In humans, the effects of these viruses are correlated with viral pneumonia, severe respiratory tract infections. It is believed that interaction between angiotensin converting enzyme 2 (ACE2) cell receptor and viral Spike protein mediates the coronavirus entry into human respiratory epithelial cells and establishes the host tropism. ACE2 receptor is highly expressed in airway epithelial cells. Along with viral-receptor interaction, proteolytic cleavability of S protein has been considered as the determinant of disease severity. Several studies highlight the occurrence of impaired host immune response and expression of excessive inflammatory response especially cytokines against viral infection. The mechanisms of SARS-CoV-2 induced acute lung injury are still undefined; however, the term cytokine storm has now been recognized to be closely associated with COVID-19. The levels of inflammatory mediators from cytokine storm cause damage to the host cells. In particular, the proinflammatory cytokine IL-6 appears to be the key mediator in early phase of virus-receptor interaction; however, secreted IL-6 might not be representative of lung inflammation. Understanding the cellular, and molecular factors involved in immune dysregulation and the high virulence capacity of COVID-19 will help in potential targeted therapy against it. “Drug repurposing” and “molecular docking analysis” is considered as an attractive alternative approach in analyzing suitable drug candidates to combat SARS-CoV-2 infection. Globally, extensive research is in progress to discover a new vaccine for novel COVID-19. Moreover, our review mainly focuses on the most state-of-the-art therapeutic approach mediated by “Mannose-binding lectin (MBL).” One of the most significant molecules of innate immunity is MBL. It plays a major role in the activation of the complement system as an ante-antibody prior to the response of any particular antibody. Recombinant human MBL can be used as immunomodulators against SARS-CoV-2.

Uptake of liposomes modified with Man6 or Man8 by native cells was enhanced but did not reach an optimum. Thus, Man6, Man8, and mannosides with even longer spacer arms are of potential use in receptor-mediated targeting.

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Stereoselective synthesis of glycosides (glucosides, galactosides, mannosides, and xylosides) is reported using long-chain alcohols with 0-4 ethoxy spacers as potential anchored cryoprotectors.Glycolipids are one of the basic constituents of biological membranes besides phospholipids. The sugar residues in these membranes on the cell surface are playing an important role in the biological response. With this goal we have tried to analyze the influence of different sugar units on the physicochemical properties of phospholipid systems, especially hydration"] and the behavior of lipid systems during water removal under freezing condition and desiccation (lyophilization)[21 and also on the interaction between phospholipidglycolipid systems with cells131. Glycosides of long- R'OR chain alcohols are of our special interest because of the homogeneity of their mixture with phosphatidyl choline to an unlimited extent, also resulting to the formation of lipid vesicles in these mixturesr41. For these investigations we required some glycosides of different sugars with long-chain alkyl groups and with spacers containing a different number of ethyleneoxy groups between sugar and alkyl moiety.Although a number of methods [5] are known in the literature for glycosidation, none of the three existing main methods, namely the Koenigs-Knorr method, the Lewis acidcatalyzed process and the synthesis using a phase-transfer catalyst (PTC) provides good stereoselectivity in good overall yield, particularly with long-chain alcohols because of their low reactivity. Especially cis glycosidation is still prob-