Cardiovascular instability Venous pooling in the legs can result in significant hypotension particularly in elderly patients (Table 2). Surgical stimulation of the lower pons, upper medulla, floor of the fourth ventricle Key points The posterior fossa or the infratentorial fossa is a rigid compartment with poor compliance and houses important structures such as the brainstem and cerebellum.
In this prospective, single-centre, slightly underpowered, double-blind randomised controlled trial (RCT) with intention-to-treat analysis, use of moderate-dose hydrocortisone in etomidate-related adrenal insufficiency was not shown to reduce the proportion of patients with a cardiovascular Sequential Organ Failure Assessment (SOFA) score of 3 or 4. Level of evidence: 2B (CEBM, low quality RCT)
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