Noninvasive magnetoencephalography makes it possible to identify the cortical area in the human brain whose activity reflects the decay of passive sensory storage of information about auditory stimuli (echoic memory). The lifetime for decay of the neuronal activation trace in primary auditory cortex was found to predict the psychophysically determined duration of memory for the loudness of a tone. Although memory for the loudness of a specific tone is lost, the remembered loudness decays toward the global mean of all of the loudnesses to which a subject is exposed in a series of trials.
The minimum norm least-squares approach based on lead field theory provides a unique inverse solution for a magnetic source image that is the best estimate in the least-squares sense. This has been applied to determine the source current distribution when the primary current is confined to a surface or set of surfaces. In model simulations of cortical activity of the human brain, the magnetic field pattern across the scalp is interpreted with prior knowledge of anatomy to yield a unique magnetic source image across a portion of cerebral cortex, without resort to an explicit source model.
Magnetic field variations from the human brain produced by visual stimulation have been observed in a normal laboratory setting with a superconducting quantum interference device and no magnetic shielding of the subject. Previously unknown temporal and spatial features of the field near the scalp are reported.
An experimental study of induced-current electrical impedance tomography verifies that image quality is enhanced by employing six rather than three induction coils by increasing the number of independent measurements. However, with an increasing number of coils, the inverse problem becomes more sensitive to measurement noise. Using 16 electrodes to measure surface voltages, it is possible to collect 6 x 15 = 90 independent measurements. For comparison purposes, images of two-dimensional conductivity perturbations are reconstructed by using the data for three and six coils with the truncated pseudoinverse algorithm. By searching for the optimal truncation index that minimizes the noise error plus the resolution error, the signal-to-noise ratio of the data acquisition system was established as 58 db. Images obtained with this six-coil system reveal the sizes and locations of the conductivity perturbations. This system also provides images within the central region of the object space, a capability not achieved in previous experimental studies using only three circular coils. Nevertheless, the three-coil system can identify the conductivity perturbations near the periphery. However, it displays shifts in the locations and spread in the sizes of perturbations near the center of the object.
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