Photodynamic therapy simultaneously reduces plaque inflammation and promotes repopulation of plaques with a SMC-rich stable plaque cell phenotype while reducing disease progression. These early healing responses suggest that PDT is a promising therapy for the treatment of acute coronary syndromes.

Objective: To examine the effects of intracoronary PhotoPoint photodynamic therapy (PDT) with a new photosensitiser, MV0611, in the overstretch balloon and stent porcine models of restenosis. Methods: 28 pigs were injected with 3 mg/kg of MV0611 systemically 4 h before the procedure. Animals were divided into either the balloon overstretch injury (BI) group (n = 19) or the stented group (n = 9). After BI, a centred delivery catheter was positioned in the artery to cover the injured area, and light (532 nm, 125 J/cm2 ) was applied to activate the drug (n = 10). Control arteries (n = 9) were not activated by light. In the stented group, the drug was light activated before stent deployment. Serial sections of vessels were processed 14 days after treatment in the BI group and 30 days after treatment in the stented group for histomorphometric or immunohistochemical analysis.

No abstract

It is shown that Lennard-Jones parameters are not g o d correlating factors; the implications of this fact on the type of interaction potential effective for energy transfer from highly excited molecules are discussed.We have demonstrated reverse saturable absorption of picosecond pulses at 532 nm using the organometallic tetramer cyclopentadienyliron carbonyl [ (C5H5)Fe(CO)], dissolved in methylene chloride. Time-resolved pumpprobe measurements and numerical simulations based on a five-level model indicate that reverse saturable absorption of ultrafast optical pulses is due to excited singlet absorption in this tetramer. We have determined the lifetime of the first excited singlet state to be 120 ps, and have measured a singlet excited-state capture cross-section of 8 X lo-'* cm2, twice that of the ground-state cross-section. In addition, we have placed bounds on the lifetime of the second excited singlet state and the branching ratio between the singlet and triplet systems.

Variations of the organometallic cluster known as King's complex, [ (CsH~)Fe(C0)14, have been synthesized to study the excited-state transition responsible for reverse saturable absorption observed at 532 nm in this molecule. Picosecond pumpprobe measurements have been used to measure the excited-state cross sections and lifetimes in King's complex and the analogs methyl-King's complex, [CH3(C5H4)Fe(C0)I4, and triethylaluminum King's complex, [ (CsH5)Fe(COAl(C2H5)3)]4. Within experimental error, the excited-state parameters are unaffected by alterations to either the carbonyl or the cyclopentadienyl ligand of the King's complex. These results are consistent with an excited-state absorption resulting from a second d to d transition within the singlet states of the metal core.