Overall, responders to omalizumab therapy are less likely to experience an asthma exacerbation and hospitalization. They were also more likely to reduce maintenance corticosteroid therapy and the need for rescue reliever therapy. These data suggest that omalizumab has proven effective in improving health outcomes for a cohort of carefully selected patients with severe allergic asthma in Ireland.

The findings of the study demonstrate that the use of transcricoid injection of lignocaine provided a safe adjunct for anaesthesia in flexible bronchoscopy.

Aim: To evaluate the effectiveness of periodontal ligament injection of 2% lidocaine with 1:80,000 adrenaline in producing profound pulp anaesthesia and soft tissue anaesthesia. Materials and Methods: The sample of this study included 120 dental students, 72 males and 48 females, ranging in age from 18 to 23 years. The periodontal injection was administered to the periodontal space on the mesial and distal aspects of the central incisor, first premolar and first molar of both arches. The injection was administered by a standard dental syringe using 0.2 ml of 2% lidocaine with 1:80,000 adrenaline. The pulp anaesthesia was evaluated by electric pulp tester and soft tissue anaesthesia was evaluated by probing. Results: The success rate of pulp anaesthesia in this study was 57.5% (60% in the maxilla and 55% in the mandible). In both arches, first premolar and first molar teeth showed a significantly higher success rate than that of central incisor (p<0.05). The mesial and distal teeth, adjacent to the injected tooth, were anaesthetized in 29.7% and 40.8% respectively. No significant difference was noted in the success rate of pulp anaesthesia between mesial and distal teeth (p>0.05). The duration of pulp anaesthesia was 18.34 minutes. The duration of pulp anaesthesia was significantly longer in the mandibular than maxillary teeth (p<0.05). The extent of associated soft tissue anaesthesia was 14.77mm on the labial (buccal) aspect and 11.18 mm on the lingual (palatal) aspect. No significant difference was noted, in both arches, in the extension of soft tissue anaesthesia on both aspects (p>0.05). Conclusion: The periodontal ligament injection anaesthesia has a higher success rate in premolars and molars as compared to incisors. The duration of pulp anaesthesia was 18.34 minutes. The extent of soft tissue anaesthesia was 14.77 mm on the labial aspect and 11.18 mm on the lingual aspect.

This study was carried out to assess the success rate of apicectomy of anterior and premolar teeth. Out of 336 patients, who had undergone apicectomy in a private practice between 1997-2001, only 256 patients (76.2%) completed the two years recall visits; which was the minimum time recommended in this study to judge whether the operation was successful or not. The age range of the patients was 12-67 years (mean of 34.7 years), 136 were males and 120 were females. The overall success rate of apicectomy in this study was 89.1%. Sex of the patient had no bearing on the success rate (p > 0.05). Highly significant influence of the patient's age on the success rate was observed (p < 0.01); the success rate increased proportionally with increased age. Highly significant influence of the type of the apicectomised tooth on the success rate was noted (p < 0.001); upper anterior teeth showed the highest success rate (92.1%), whereas upper premolars showed the lowest success rate (77.4%). Periapical condition of the tooth prior to the operation, preoperative vs postoperative obturation of the root canal, and orthograde obturation vs retrograde obturation were not significant factors affecting the success rate of apicectomy (p > 0.05).