Taking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin ototoxicity (rs1872328, P = 3.9×10-8, hazard ratio = 4.5) in 238 children with newly-diagnosed brain tumors, with independent replication in 68 similarly treated children. ACYP2 risk variant strongly predisposed patients to precipitous hearing loss and was related to ototoxicity severity. These results point to novel biology of ototoxic effects of platinum agents.
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