Background: ARHGAP21 is an important Rho-GAP for Cdc42 involved in vesicle trafficking and focal adhesion kinase activity. Results: ARHGAP21 participates in cell-cell adhesion formation and cellular migration, interacts and modulates ␣-tubulin acetylation, and is essential for epithelial-mesenchymal transition. Conclusion: ARHGAP21 is a novel ␣-tubulin partner coordinating cell-cell adhesion, migration, and epithelial-mesenchymal transition. Significance: ARHGAP21 might be involved in cancer metastasis.
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