We developed two reactions needed for a total synthesis of phenoxan, a naturally occurring compound with anti‐HIV activity. In this Note, we further examined these two issues: metallation of a 2‐methyl‐oxazole and formation of a pyran‐4‐one. We employed these methods for the preparation of a phenoxan analog.
An Approach to Substituted 4-Hydroxypyran-2-ones: The Total Synthesis of Phenoxan.-The title compound (XI) of anti-HIV activity is synthesized with the metalation of (II) and the preparation of (IX) as key steps. -(GAREY, D.; RAMIREZ, M.; GONZALES, S.; WERTSCHING, A.; TITH, S.; KEEFE, K.; PENA, M. R.; J.
Synthetic Studies Toward Phenoxan Analogues. -Two reactions for the synthesis of phenoxan analogue (XII) are developed: metalation of 2-methyloxazole (III) and formation of a pyran-4-one (X). -(ZHANG, X.; HINKLE, B.; BALLANTYNE, L.; GONZALES, S.; PENA, M. R.; J.
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