OBJETIVOS: descrever as características clínicas dos pacientes com hiperfenilalaninemia acompanhados no Serviço de Referência em Triagem Neonatal (SRTN) do estado da Bahia. MÉTODOS: estudo descritivo transversal, tendo como amostra todos os pacientes com diagnóstico conhecido de Hiperfenilalaninemia residentes no estado da Bahia e acompanhados no SRTN até setembro de 2005. Tal população é composta de 46 famílias, num total de 51 pacientes. A análise dos dados foi descritiva, incluindo medidas de tendência central e dispersão. RESULTADOS: houve discreto predomínio do gênero feminino (52,9%). A maioria dos pacientes (78,4%) teve seu diagnóstico estabelecido através da triagem neonatal, tendo, portanto, tratamento precoce. Consangüinidade foi registrada em 32,6% das famílias. A média de início do tratamento entre os pacientes diagnosticados pela triagem neonatal foi de 56,6 37,8 dias, enquanto que entre os pacientes com diagnóstico tardio, foi de 7,1 anos. CONCLUSÕES: o estudo descreve um grupo de pacientes representativo de uma patologia incluída no Programa Nacional de Triagem Neonatal (PNTN), sendo, portanto, de relevância para a saúde pública. Entre os dados clínicos, chama a atenção a média de idade do início do tratamento, superior ao recomendado na literatura, alertando para a necessidade de um maior enfoque no diagnóstico precoce.
Objectives: Constipation affects up to 30% of children. Insufficient fiber intake is associated with functional constipation and changes in dietary composition, such as the addition of prebiotics, may improve stool pattern. There are few studies suggesting some effect of dietary management in childhood constipation. We obtained information on the incidence of constipation as part of a recently completed randomized trial designed to assess the effect of a follow‐up formula with prebiotics on the occurrence of acute respiratory infections and diarrheal disease in children from two daycare centers in Brazil. Methods: In this double‐blind, randomized, controlled trial, healthy 1‐4 year old children were fed 3 servings/day of a cow’s milk‐based follow‐up formula fortified with micronutrients, docosahexaenoic acid, yeast beta‐glucan, and the prebiotics polydextrose (PDX) and galactooligosaccharides (GOS) (FF; n=125) or an unfortified cow's milk‐based beverage (C; n=131) for 28 weeks. A child was considered constipated if at least 2 of the 3 following symptoms were present for at least 2 uninterrupted weeks: presence of hard stools, difficulty or pain to defecate, and an interval of more than 72 hours without defecation. The children who met these criteria were categorized by age at study entry (12‐24 months or 25‐48 months) and compared using the Fisher’s exact test. Results: Twenty four of the 158 children in the 25‐48 month age category (15%) met the criteria for constipation. Fewer children in this age category remained constipated at the end of the study in the FF group compared to the control group (Table). The difference was not statistically significant (p=0.27), most likely due to the small number of participants in each formula group who met the criteria for constipation. In the 12‐24 month age category, 8 of 98 children (8%) met the criteria for constipation. However, all were in the control group, and 5 of the 8 (63%) remained constipated at the end of the study. Conclusion: These results suggest that dietary modification such as addition of the prebiotic fibers PDX and GOS may alleviate functional constipation in children.
The aim of this study is to compare pregnancy outcomes between women older than 35 years and a control group composed by younger patients. Materials and Methods: The study involves pregnant women admitted to the present Department from January 1, 2015 to December 31, 2015. Enrolled pregnants were divided into two groups: group 1 ("cases") included women over 35 years and group 2 ("controls") included women younger than 35 years. Clinical data were collected through the patients' obstetrical files. Results: Study population was composed of 2,030 patients, divided into two groups: group 1 including 844 women and group 2 including 1,186 women. The authors analysed clinical and obstetrical data regarding spontaneous miscarriage (SM), elective pregnancy termination (EPT), mode of delivery, incidence of obstetrics complications, and neonatal outcome. Conclusions: Women of advanced maternal age (AMA) have a greater risk to develop several obstetric complications. It is very important to follow them closely in order to detect early complications and obtain better pregnancy outcome.
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