We present an all-polymer photonic sensing platform based on whispering-gallery mode microgoblet lasers integrated into a microfluidic chip. The chip is entirely made from polymers, enabling the use of the devices as low-cost disposables. The microgoblet cavities feature quality factors exceeding 10(5) and are fabricated from poly(methyl methacrylate) (PMMA) using spin-coating, mask-based optical lithography, wet chemical etching, and thermal reflow. In contrast to silica-based microtoroid resonators, this approach replaces technically demanding vacuum-based dry etching and serial laser-based reflow techniques by solution-based processing and parallel thermal reflow. This enables scaling to large-area substrates, and hence significantly reduces device costs. Moreover, the resonators can be fabricated on arbitrary substrate materials, e.g., on transparent and flexible polymer foils. Doping the microgoblets with the organic dye pyrromethene 597 transforms the passive resonators into lasers. Devices have lasing thresholds below 0.6 nJ per pulse and can be efficiently pumped via free-space optics using a compact and low-cost green laser diode. We demonstrate that arrays of microgoblet lasers can be readily integrated into a state-of-the-art microfluidic chip replicated via injection moulding. In a proof-of-principle experiment, we show the viability of the lab-on-a-chip via refractometric sensing, demonstrating a bulk refractive index sensitivity (BRIS) of 10.56 nm per refractive index unit.
Optical micro-resonators have broad applications. They are used, for example, to enhance light–matter interactions in optical sensors or as model systems for investigating fundamental physical mechanisms in cavity quantum electrodynamics. Coupling two or more micro-cavities is particularly interesting as it enlarges the design freedom and the field of application. In this context, achieving tunability of the coupling strength and hence the inter-cavity gap is of utmost importance for adjusting the properties of the coupled micro-resonator system. In this paper, we report on a novel coupling approach that allows highly precise tuning of the coupling gap of polymeric micro-resonators that are fabricated side by side on a common substrate. We structure goblet-shaped whispering-gallery-mode resonators on an elastic silicone-based polymer substrate by direct laser writing. The silicone substrate is mechanically stretched in order to exploit the lateral shrinkage to reduce the coupling gap. Incorporating a laser dye into the micro-resonators transforms the cavities into micro-lasers that can be pumped optically. We have investigated the lasing emission by micro-photoluminescence spectroscopy, focusing on the spatial localization of the modes. Our results demonstrate the formation of photonic molecules consisting of two or even three resonators, for which the coupling strengths and hence the lasing performance can be precisely tuned. Flexibility and tunability are key elements in future photonics, making our approach interesting for various photonic applications. For instance, as our coupling approach can also be extended to larger cavity arrays, it might serve as a platform for tunable coupled-resonator optical waveguide devices.
Whispering-gallery mode (WGM) microdisk lasers show great potential for highly sensitive label-free detection in large-scale sensor arrays. However, when used in practical applications under normal ambient conditions, these devices suffer from temperature fluctuations and photobleaching. Here we demonstrate that these challenges can be overcome by a novel referencing scheme that allows for simultaneous compensation of temperature drift and photobleaching. The technique relies on reference structures protected by locally dispensed passivation materials, and can be scaled to extended arrays of hundreds of devices. We prove the viability of the concept in a series of experiments, demonstrating robust and sensitive label-free detection over a wide range of constant or continuously varying temperatures. To the best of our knowledge, these measurements represent the first demonstration of biosensing in active WGM devices with simultaneous compensation of both photobleaching and temperature drift.
Microgoblet laser pairs are presented for cross‐referenced on‐chip biomolecular sensing. Parallel readout of the microlasers facilitates effective mutual filtering of highly localized refractive index and temperature fluctuations in the analyte. Cross‐referenced detection of two different types of proteins and complete chemical transducer reconfiguration is demonstrated. Selective surface functionalization of the individual lasers with high spatial accuracy is achieved by aligned microcontact stamping.
We present a multi-sensor chip comprising an array of whispering-gallery mode (WGM) micro-goblet lasers integrated into a digital microfluidic (DMF) system. In contrast to earlier demonstrations, the lasers are fabricated from dye-doped poly-methyl methacrylate (PMMA) at low cost using spin-coating, mask-based optical lithography, wet chemical etching, and thermal reflow techniques. Pumping and read-out of the devices is accomplished via simple free-space optics, thereby allowing large-scale sensor arrays to be addressed. We demonstrate the viability of the system by bulk refractive index-sensing and by measuring the specific binding of streptavidin to a biotinylated sensor surface. This is the first time that optical cavities are used for label-free detection of biomolecules in a DMF system. This approach can be extended to a versatile detector platform that targets a wide range of clinically relevant biomolecules.
Integration of optically active materials into whispering gallery mode (WGM) cavities enables low-threshold laser emission. In contrast to their passive counterparts, the WGMs of these microlasers can be pumped and read out easily via free-space optics. The WGMs interact with the cavity environment via their evanescent field, and thus lend themselves to label-free bio-sensing. The detection limit of such sensors, given as the ratio of the resolution of the whole measurement system to the sensitivity of the WGMs, is an important figure of merit. In this work we show that the detection limit of polymeric microdisk lasers can be improved by more than a factor of seven by optimizing their radius and thickness. We use the bulk refractive index sensitivity, the magnitude of the sensor reaction towards refractive index changes of the bulk environment, to quantify the sensing performance and show that it can be enhanced while the spectral resolution is maintained. Furthermore, we investigate the effect of the size of the cavity on the quality factor and the lasing threshold in an aqueous environment, hence allowing optimization of the cavity size for enhanced sensor performance. For all considered quantities, numerically computed expectations are verified by experimental results.
Silicon nitride (Si 3 N 4) waveguides offer low-loss wave propagation over a wide spectral range including visible wavelengths and lend themselves to photonic integrated circuits for bio-photonic applications. The Si 3 N 4 device portfolio, however, is so far limited to passive devices that need to be fed by external light sources. This often requires delicate and costly fiber-chip coupling schemes that are subject to stringent alignment tolerances. In this paper, we present and investigate a class of lasers that combine Si 3 N 4 waveguides with light-emitting organic cladding materials in a hybrid approach. These Si 3 N 4-organic hybrid (SiNOH) lasers are operated by optical pumping from the top with low alignment precision. We theoretically and experimentally investigate different SiNOH laser concepts based on spiral-shaped ring resonators and distributed feedback (DFB) resonators. While our devices are designed for an emission wavelength of approximately 600 nm, the SiNOH laser concept can be transferred to a large range of wavelengths in the visible spectrum. The devices are amenable to cost-efficient mass production and have the potential to address a wide range of applications in bio-photonics and point-of-care diagnostics.
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